Project Lead

Dr Emma Boehm

Dr Emma Boehm

The pseudohypoxic cluster of phaeochromocytoma and paraganglioma (PPGL) has a high metastatic potential, and there are few effective treatments for metastatic disease. Improvement in non-invasive diagnostics is of clinical importance. This project has the following aims:

1. Use PPGL gene-expression data to catalogue known and putative targets for positron emission tomographic (PET) imaging for diagnosis/surveillance as well as radionuclide therapy.
2. Analyse circulating tumour DNA in patients with late-stage metastatic PPGL for causative mutations and diagnostic/therapeutic targets
3. Develop a preclinical model of a pseudohypoxic PPGL subtype in order to test a candidate radiopharmaceutical