The development and validation of a physiological haemodynamic model of the right heart and pulmonary circulation for use in the perioperative period.

Pulmonary hypertension is associated with significant morbidity and mortality in the perioperative period due to the risk of acute right ventricular dysfunction. Accurate haemodynamic assessment in these patients is a difficult but necessary step in management. I aim to develop and evaluate a physiological model of the right heart and pulmonary circulation for the real-time evaluation of pulmonary haemodynamics using retrospective data from patients undergoing right heart catheterisation. I will then validate my model in a pre-clinical ovine laboratory under a range of physiological and pathological states. Thereafter, I will apply the model prospectively to perioperative patients.