Development and implementation of a shotgun metagenomic- based approach for microbiome characterisation.

The aim of this research program is develop and implement a highly reproducible and accredited laboratory test to characterise the human microbiome using a shotgun metagenomic-based approach. Once implemented, this approach will be utilised to firstly define the normal microbiome in the Australian context, and subsequently to comprehensively characterise the microbiome of individuals in diseases states, such as those at high risk of invasive infection with multi-drug resistant organisms.